화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.34, No.2, 178-183, March, 2010
Export Citation
생분해성 고분자의 전기분사를 이용한 약물방출 스텐트용 금속표면 코팅 및 ALA방출 거동
Metal Surface Coating Using Electrospray of Biodegradable Polymers and α-Lipoic Acid Release Behavior for Drug-Eluting Stents
김동민1, 2, 이봉수1, 박철호1, 박귀덕1, 손태일2, 정명호3, 한동근1, †
  • 1한국과학기술연구원 바이오소재센터
  • 2중앙대학교 생명공학과
  • 3전남대학교병원 심장질환 특성화 연구센터
Dong Min Kim1, 2, Bong Soo Lee1, Cheol Ho Park1, Kwideok Park1, Tae-Il Son2, Myeong Ho Jeong3, and Dong Keun Han1, †
  • 1Biomaterials Center, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea
  • 2Department of Biotechnology and Bio-Environmental Technology(BET) Research Institute, Chung-Ang University, 72-1, Nae-Ri, Daedeok-Myeon, Anseong, Gyeonggi-Do 456-756, Korea
  • 3Heart Research Center of Chonnam National University Hospital, Jaebongro 671, Donggu, Gwangju 501-757, Korea
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초록
의료용 금속스텐트는 관상동맥계 심장질환을 앓고 있는 환자에 시술되어 상대적으로 생존율을 높여 준다. 그러나, 재협착 및 후기 혈전증으로 인하여 새로운 스텐트의 개발이 시급하게 되었다. 이러한 문제점을 해결하기 위해서 신생내막 과대증식을 막을 수 있는 것으로 알려진 alpha lipoic acid(ALA)를 생분해성 고분자인 poly(lactide-coglycolide)(PLGA), poly(L-lactide)(PLLA) 및 poly(ε-caprolactone)(PCL)과 혼합하여 전기분사 방식으로 스테인레스 스틸 표면 위에 코팅하였다. 코팅된 고분자로부터 약물방출 거동은 고분자의 종류와 농도, 용출속도 및 용매의 종류에 따라서 조사하였다. 약물방출 속도는 유리전이온도(Tg)가 낮은 PCL에서 가장 빨랐으며 PLGA, PLLA 순서를 보였다. 고분자 표면의 거친정도는 용출속도가 증가함에 따라서 증가하였고, 용매의 비등점의 차이에 의해서 약물방출속도가 변화됨을 알 수 있었다. 이러한 약물방출 거동을 조절함으로써 ALA가 담지된 생분해성 고분자로 코팅된 약물방출 스텐트를 실제 임상적용이 가능할 것으로 기대된다.
Medical metal stents inserted to patients with a cardiovascular disease associated with coronary artery system have relatively increased the survival rate. The development of new stents is, however, urgently required due to restenosis and late thrombosis generated in metal stents. To solve these problems, the biodegradable polymers such as poly(lactide-co-glycolide) (PLGA), poly(L-lactide)(PLLA), and poly (ε-caprolactone)(PCL) were mixed with alpha lipoic acid (ALA), which is well known to inhibit the proliferation of neointimal hyperplasia. Subsequently, the ALA-loaded polymers were coated on stainless steel by electrospray. The drug-eluting behaviors from the coated polymers were investigated according to kinds and concentrations of polymers, spray rates, and kinds of solvents. The drug-eluting rate from PCL with the lowest glass transition temperature was the fastest among three polymers and followed by PLGA and PLLA. The surface roughness increased as the spray rate was increased and also the drug-eluting rate was affected by kinds of solvents with different boiling point. It is expected that drug-eluting stent (DES) coated with ALA-loaded polymers can be applied practically for clinical applications by controlling the behavior of drug release.
Keywords:coronary artery;drug-eluting stent(DES);biodegradable polymers;alpha lipoic acid;electrospray coating
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