Journal of the American Chemical Society, Vol.131, No.50, 18042-18042, 2009
Palladium-Catalyzed Hydroalkylation of Styrenes with Organozinc Reagents To Form Carbon-Carbon sp(3)-sp(3) Bonds under Oxidative Conditions
An unconventional route for the formation of sp(3)-sp(3) C-C bonds from various styrenes and an organozinc reagent in a formal alkene hydroalkylation process is detailed. Mechanistically, this process is proposed to proceed by initial transmetalation followed by formation of a Pd-H species, which is subsequently trapped by the styrene.