Journal of the American Chemical Society, Vol.130, No.47, 15786-15786, 2008
Direct Catalytic Asymmetric Synthesis of Cyclic Aminals from Aldehydes
A highly enantioselective Bronsted acid catalyzed direct synthesis of cyclic aminals from aldehydes has been developed. The methodology has been applied to the first asymmetric synthesis of several anti hypertensive aminal drugs including (R)-Thiabutazide.