Journal of the American Chemical Society, Vol.130, No.32, 10504-10504, 2008
Platinum-catalyzed intramolecular vinylchalcogenation of alkynes with beta-phenylchalcogeno conjugated amides
Platinum-catalyzed intramolecular vinylthiolation and -selenation of internal alkynes with vinylchalcogenides 1 having a carbamoyl group on cis-beta-position of vinyl moiety was developed. The conjugated six-membered lactam framework 2 was constructed in 1 high yields. Density functional theory calculations for alkyne insertion processes suggest seven-membered platinacycle 3 is a kinetically favored intermediate of this catalytic system.