Model predictive control (MPC) schemes are now widely used in process industries for the control of key unit operations. Linear model predictive control (LMPC) schemes which make use of linear dynamic model for prediction, limit their applicability to a narrow range of operation (or) to systems which exhibit mildly nonlinear dynamics. In this paper, a nonlinear observer based model predictive controller (NMPC) for nonlinear system has been proposed. An approach to design NMPC based on fuzzy Kalman filter (FKF) and augmented state fuzzy Kalman filter (ASFKF) has been presented. The efficacy of the proposed NMPC schemes have been demonstrated by conducting simulation studies on the continuous stirred tank reactor (CSTR). The analysis of the extensive dynamic simulation studies revealed that, the NMPC schemes formulated produces satisfactory performance for both servo and regulatory problems. Simulation results also include an inferential control case, where the reactor concentration is not measured but estimated from temperature measurement and used in the NMPC based on FKF and ASFKF formulations. (c) 2007 Elsevier Ltd. All rights reserved.