Journal of Molecular Catalysis A-Chemical, Vol.292, No.1-2, 44-48, 2008
LiCO4/Et3N: Highly efficient and active catalyst for selective Michael addition of active methylene compounds under solvent-free condition
A simple catalyst LiClO4/Et3N has been developed and demonstrated to efficiently catalyze Michael addition reactions of active methylene compounds to conjugated ketones, nitriles, esters and nitroalkenes with remarkably high yields and in short reaction time. The Michael addition to nitroalkenes and alpha,beta-unsaturated ketones proceeds quantitatively in the usual way, giving the monoaddition product. (C) 2008 Elsevier B.V. All rights reserved.