The widely utilization of pharmaceutical and personal care products (PPCPs) in the pharmaceutical therapies and agricultural husbandry has led to the worldwide pollution in the environment. In this study, the photoelectrocatalytic (PEC) behaviors of typical PPCPs, tetracycline (TC), were performed via a highly effective TiO2 nanopore arrays (TNPs) electrode, comparing with electrochemical (EC) and photocatalytic (PC) process. A significant photoelectrochemical synergetic effect in TC degradation was observed on the TNPs electrode and the rate constant for the PEC process of TNPs electrode was similar to 6.7 times as high as its PC process. The TC removal rate achieved similar to 80% within 3 h PEC reaction by TNPs electrode, which is similar to 25% higher than that obtained for a conventional coated TiO2 nanofilm electrode fabricated by sol-gel method. The possible mechanism involved in the PEC degradation of TC by TNPs electrode was discussed. Furthermore, the TNPs electrode also shows enhanced photocurrent response compared with that for the coated TiO2 nanofilm electrode. Such kind of TiO2 nanopores will have many potential applications in various areas as an outstanding photoelectrochemical material. (C) 2009 Elsevier B.V. All rights reserved.