In the large cities, the disordered urban development, the industrial activities, and the transport, have caused elevated concentrations of polluting agents and possible risks to the health of the population. The metropolises located in valleys with little ventilation (such as the Urban Area of Guadalajara: UAG) present low dispersion Of Polluting agents can cause high risk of respiratory and cardiovascular diseases. The objective of this work was to describe the spatial-temporal distribution of the atmospheric polluting agents: carbon monoxide (CO), nitrogen dioxide (NO2), sulfur dioxide (SO2), Particles smaller than 10 microns (mu m) (PM10) and ozone (O-3) in the UAG during the period 2000-2005. A spatial-temporal distribution analysis was made by means of graphic interpolation (Kriging method) of the statistical parameters of CO, NO2, SO2, PM10 and O-3 with the collected data from eight stations of atmospheric monitoring in the UAG. The results show that the distributions of the atmospheric polluting agents are variable during the analyzed years. The polluting agent with highest concentration is PM10 (265.42 mu g/m(3)), followed by O-3 (0-11 ppm), NO2 (0-11 ppm), CO (9.17 ppm) and SO2 (0.05 ppm). The most affected zone is the southeast of the UAG. The results showed that an important percentage of days exceed the Mexican norms of air quality (93-199 days/year). (c) 2008 Published by Elsevier B.V.