The main goal of this work is to determine the effects of pollution of copper, lead and zinc mines on the Eastern Black Sea. Metal and heavy metal concentrations in the Eastern Black Sea mussels were measured using Energy Dispersive X-ray Fluorescence (EDXRF) and Flame Atomic Absorption Spectroscopy (FAAS). The analytical results showed that the tissue of mussel in Eastern Black Sea contains K, Ca, Fe, Cu, Zn, and Sr elements, and the shell of mussel contains Ca, Cu, Sr, and Ba elements. Due to the detection limit of EDXRF, the mussels were analyzed with FAAS for Cr, Mn, Ni, Cd and Pb elements. An ANOVA and Pearson correlation analyses were performed The results showed although that the mean concentrations of Cu. and Zn for the tissue of the mussels were markedly above the permissible levels of the Turkish regulations Zn concentration is in the limits of the Food and Agriculture Organization (FAO). (C) 2008 Elsevier B.V. All rights reserved.