This work introduces a semi-natural wetland biomonitoring framework for heavy metal concentrations based on a robust dynamic integration between biological assemblages and relevant biosensors. The cooperative/synergistic scheme developed minimizes uncertainty and monitoring costs and increases reliability of pollution control and abatement. Attention is given to establishing a fully functioning and reliable network approach for monitoring inflows and achieving dose-response relations and calibration of biomonitoring species. The biomonitoring network initially consists of both, biosensors and species, its a validation phase in each wetland of the surveillance area once the species monitoring efficiency is verified by the biosensors, the biosensor network moves to the next wetland and so on, following a circular Pattern until all area wetlands have a fully functional natural monitoring scheme. By means of species recalibration with periodic revisiting of the biosensors, the scheme progressively reaches a quasi steady-state (including seasonality), thus ensuring reliability and robustness. This framework, currently pilot-tested in Voiotia, Greece, for assessing chromium levels, has been built to cover short-, -medium and long-term monitoring requirements. The results gathered so far, support the employment of the proposed scheme in heavy metal monitoring, and. further, arise the need for volunteer involvement to achieve long-term viability. (c) 2008 Elsevier B.V. All rights reserved.