In the framework of pattern dynamics approach, the discrete bubble model was developed for simulating inherent fluctuation of void fraction in a horizontal two-phase flow. Then flow patterns were identified based on the statistical properties of void fraction fluctuation, and the flow pattern map agreed with the experimental observation of high-pressure two-phase flow Of CO2 in horizontal tubes. The time-averaged pressure drop and the void fraction obtained in the simulation agreed reasonably with the existing correlations. Thus the horizontal flow version of the discrete bubble model demonstrates its relevance in simulating inherent fluctuation of two-phase flow. (C) 2009 Elsevier Ltd. All rights reserved.