A detailed experimental study of flow through long microchannels of hydraulic diameter ranging from 60.5 to 211 mu m has been carried out. The internal pressure distribution along the length of the channel has been measured to analyze the local flow behaviour. The effects of compressibility and transition to turbulence occurring in the microchannel flow were investigated in detail. In addition, the resulting flow has been analyzed numerically using a commercially available CFD code, FLUENT. It has been shown that there are no special micro-scale effects, including early transition to turbulence at least in the present range of hydraulic diameters after the significant effects of compressibility are accounted appropriately. (C) 2009 Elsevier Ltd. All rights reserved.