The present research work concerns development of regression models to predict the monthly heating demand for single-family residential sector in temperate climates, with the aim to be used by architects or design engineers as support tools in the very first stage of their projects in finding efficiently energetic solutions. Another interest to use such simplified models is to make it possible a very quick parametric study in order to optimize the building structure versus environmental or economic criteria. All the energy prediction models were based on an extended database obtained by dynamic simulations for 16 major cities of France. The inputs for the regression models are the building shape factor, the building envelope U-value, the window to floor area ratio, the building time constant and the climate which is defined as function of the sol-air temperature and heating set-point. If the neural network (NN) methods could give precise representations in predicting energy use, with the advantage that they are capable of adjusting themselves to unexpected pattern changes in the incoming data, the multiple regression analysis was also found to be an efficient method, nevertheless with the requirement that an extended database should be used for the regression. The validation is probably the most important level when trying to find prediction models, so 270 different scenarios are analysed in this research work for different inputs of the models. It has been established that the energy equations obtained can do predictions quite well, a maximum deviation between the predicted and the simulated is noticed to be 5.1% for Nice climate, with an average error of 2%. In this paper, we also show that is possible to predict the building heating demand even for more complex scenarios, when the construction is adjacent to non-heated spaces, basements or roof attics. (C) 2008 Elsevier B.V. All rights reserved.