The kinetics of oxidation of I-butanol/n-heptane mixtures (20/80 and 50/50 in mol) was Studied experimentally using a fused silica jet-stirred reactor. The experiments were performed in the temperature range 530-1070 K, at 10 atm, at two equivalence ratios (0.5 and 1), and with an initial fuel concentration of 750 ppm. A kinetic modeling was performed using reaction mechanisms resulting from the merging of validated kinetic schemes for the oxidation of the components of the present mixtures (n-heptane and butanol). Good agreement between the experimental results and the computations was observed under the present conditions when using detailed chemistry, whereas using semidetailed chemistry yielded a less-accurate prediction of the fuel Oxidation kinetics.