A novel macroporous bead adsorbent. Fe(III)-loaded ligand exchange cotton cellulose adsorbent [Fe(III) LECCA], is synthesized for selective adsorption of arsenate anions [As(V)] from drinking water in batch and column systems. As(V) adsorption on Fe(III)LECCA was independent of pH, especially in drinking water pH range. Film diffusive control mechanism will benefit As(V) exchange with Fe(III)LECCA whether in batch or in column experiments. When treating the tap water at 26.0 BV/h, the column still preserves 83% of the original saturation adsorption capacity of the As(V) aqueous solution. These results have indicated that Fe (III)LECCA has the potential to act as an adsorbent for the removal of As(V) from drinking water considering its availability, nontoxicity and cost-effectiveness. (C) 2009 Elsevier B.V. All rights reserved.