Ethylenediaminetetracetic acid (EDTA) is widely used as a decontaminating agent in nuclear industry. The presence of complexant interferes in treatment of radioactive effluent. It is therefore essential to degrade EDTA prior to chemical treatment for effective management of radioactive waste. Photocatalytic treatment of EDTA can be used as a pretreatment step. The photocatalytic degradation of EDTA has been investigated in liquid waste using Degussa P-25 titanium dioxide (TiO2) as the semiconductor photocatalyst in presence of UV light. A cylindrical photoreactor has been used for the present purpose. The process of degradation of EDTA was monitored by titrimetric method using magnesium sulphate as the titrant and Erichrome black-T as indicator. The effects of various parameters such as pH, quantity of the catalyst loading, effect of H2O2 were studied. The presence of amides was detected in the degraded waste. The radioactive liquid waste containing degraded EDTA was then subjected a chemical treatment (precipitation) step, which is generally used as a waste treatment step. Results have shown that the degradation products of EDTA does not interfere in the chemical precipitation step and gives a good decontamination factor for the treatment process compared to the radioactive liquid waste where EDTA degradation has not been carried out.