The control of ignition in a rocket engine is a critical problem for combustion chamber design. Delayed ignition may lead to high-amplitude pressure fluctuations that can damage the burner (strong ignition), whereas early ignition may fail. This paper describes a numerical study of a strong ignition sequence observed in a laboratory-scale single-injector rocket chamber ignited by a laser and fueled with gaseous oxygen and hydrogen. OH-emission images, Schlieren pictures, and pressure measurements make it possible to follow the flame propagation experimentally. The present large eddy simulation (LES) approach includes shock treatment, a six species-seven reaction chemical scheme for H-2-O-2, and a model for the energy deposition by a laser. Flame/turbulence interaction is modeled with the thickened flame concept. LES is used to compute both the filling phase (during which the gaseous hydrogen and oxygen mix) and the ignition phase. The flame location and structure, as well as the temporal evolution of the chamber pressure obtained numerically, are in good agreement with the experiment. The use of complex chemistry in the computation also allows the comparison of LES data with experimental OH-images and shows that the sensitivity of the CCD camera used to record the spontaneous emission of the OH* radical is not high enough to property locate the flame front in rich regions. The combined experimental and numerical results lead to a more detailed analysis of the ignition processes and its coupling with flow rate oscillations in the H-2 and O-2 feeding lines. (C) 2009 The Combustion Institute. Published by Elsevier Inc. All rights reserved.