Using the multiple reference frames (MRF) impeller method, the three-dimensional non-Newtonian flow field generated by a double helical ribbon (DHR) impeller has been simulated. The velocity field calculated by the numerical simulation was similar to the previous studies and the power constant agreed well with the experimental data. Three computational fluid dynamic (CFD) methods, labeled I, II and III, were used to compute the Metzner constant k(s). The results showed that the calculated value from the slop method (method I) was consistent with the experimental data. Method II, which took the maximal circumference-average shear rate around the impeller as the effective shear rate to compute ks, also showed good agreement with the experiment. However, both methods suffer from the complexity of calculation procedures. A new method (method III) was devised in this paper to use the area-weighted average viscosity around the impeller as the effective viscosity for calculating k(s). Method III showed both good accuracy and ease of use.