Chemistry Letters, Vol.38, No.8, 776-777, 2009
O-2 Binding Properties of Human Serum Albumin Quadruple Mutant Complexed Iron Protoporphyrin IX with Axial His-186 Coordination
The O-2 binding properties of complexes of iron(II) protoporphyrin IX with quadruple mutants of recombinant human serum albumin (rHSA) that provide axial His-186 coordination have been characterized; their O-2 binding parameters were similar to those of analogues having proximal His-185 and of human red blood cells.