In the present work, a series of Ni/AC, Ni-Sn/AC, and Ni-Sn-Cr/AC catalysts were prepared by incipient wetness impregnation. Activity tests were performed in a continuous flow fixed-bed reactor. The conversion of methyl acetate and selectivity of acetic anhydride reached 81.1 and 38.8% respectively over the screened Ni-Sn-Cr/AC catalyst under optimal reaction conditions. Catalysts were characterized by means of BET and XRD.