Chemistry Letters, Vol.38, No.3, 930-931, 2009
Synthesis of beta-Maltooligosaccharides of alpha-Tocopherol Derivatives by Xanthomonas campestris and Cyclodextrin Glucanotransferase and Their Anti-allergic Activity
Synthesis of beta-glucosides, beta-maltoides, and beta-maltotriosides of two alpha-tocopherol derivatives, i.e., 2,5,7,8-tetramethyl-2-(4-methylpentyl)-6-chromanol and 2,5,7,8-tetramethyl-2(4,8-dimethylnonyl)-6-chromanol, was achieved by bacterial glucosylation with Xanthomonas campestris followed by cyclodextrin glucanotransferase-catalyzed glucooligosaccharide formation. The beta-glucosides and beta-maltosides of alpha-tocopherol derivatives showed inhibitory effects on IgE antibody formation and on histamine release from rat peritoneal mast cells.