Chemistry Letters, Vol.37, No.12, 1222-1223, 2008
Cyclopropanation Reactions for the Synthesis of 2-Azabicyclo[4.1.0]heptane Derivatives with Nitric Oxide Synthase Inhibitory Activity
Synthesis of new bicyclic structures containing cyclopropanes, related to selective iNOS inhibitor ONO-1714, is described. We have evaluated the effect of the compounds obtained on the production of nitric oxide in lipopolysaccharide and interferon-gamma stimulated mouse peritoneal macrophages and on in vitro iNOS activity assays.