Chemistry Letters, Vol.37, No.10, 1080-1081, 2008
Dialkylzinc-accelerated alpha-Trifluoromethylation of Carbonyl Compounds Catalyzed by Late-transition-metal Complexes
Trifluoromethylation of ketone silyl enol ethers is found to be significantly accelerated by late-transition-metal catalysts and dialkylzincs to give alpha-trifluoromethyl ketones in good yields. Addition of dialkylzinc is the key to the high yielding alpha-trifluoromethylation of carbonyl compounds.