In this study of blinking behavior of lipase B from Candida antarctica (CALB) molecules, we consider a dynamic diffusion-controlled reactions model with two dark states and one light state in line with the well-known Michaelis-Menten enzymatic kinetics to explain the observed non-exponential blinking statistics. This model could lead to a stretched exponential decay or, t (1/2) power-law decay, depending on kinetic parameters, followed by a long-time single exponential decay. (c) 2008 Elsevier B.V. All rights reserved.