An important part in the design of homogeneous azeotropic distillation systems is the choice of the thermodynamic model to describe the vapor-liquid (V-L) equilibrium properties of the fluid mixture. In this work, an analysis of the effect of choosing different thermodynamic models for the V-L equilibrium description of several azeotropic mixtures on the design of distillation columns is presented. The selected models were found to provide a good description of the equilibrium properties of the mixtures; however, when they were applied within a design method for the separation column significant differences were found for the number of trays required for a given distillation task. Some of the difference of the resulting designs can be related to the different residue curve maps provided by each thermodynamic model.