A simple, convenient and efficient one-pot cyclocondensation reaction of 1-(2-hydroxyphenyl)-2-nitroethanone, arylaldehydes and urea using etidronic acid to furnish nitro dihydropyrimidine derivatives is described. A new and efficient protocol is developed as a homogenous catalyst for the synthesis of dihydropyrimidines using substituted omega-nitro acetophenone. Various bisphosphonic acids were examined to synthesized pyrimidines via multicomponent cyclocondensation reaction. This methodology has the advantage of excellent yields with short reaction time.