We report, for the first time to the best of our knowledge, a systematic study to relate the laser action from BODIPY dyes, doped into monolithic hybrid matrices, with the synthetic protocols of the final materials prepared via so]-gel. To this aim, the influence of both the hydrolysis time, increased in a controlled way, and the nature of the neutralization agent (pyridine, 3-aminopropyltriethoxy-silane (APS), N- [3-(trimethoxysilyl)propyl] -ethylene diamine (TSPDA), and Nl-[3-(trimethoxysilyl)propyl]diethylene triamine (TSPTA) on the laser action of PM567, incorporated into hybrid matrices based on copolymers of methyl methacrylate (MMA) and 2-hydroxyethyl methacrylate (HEMA), with methyltriethoxysilane (TRIEOS) as inorganic precursor, was analyzed. The presence of the amine-modified silane TSPDA as neutralization agent, which is able at the same time to be anchored to the inorganic network enhancing the inorganic-organic compatibility through the matrix interphase, and utilization of hydrolysis times lower than 10 minutes, increased significantly the lasing efficiency and photostability of dye. The extension of this study to the laser behavior of BODIPY dyes embedded in other different hybrid materials based on hydrolyzed-condensed copolymers of MMA with 3-(trimethoxysilyl)propyl methacrylate (TMSPMA) in a 1/1. volumetric proportion, validates the generalization of the above conclusions, which provide guides for the optimization of the synthesis of organ ic-inorganic hybrid materials with optoelectronic innovative applications independently of their composition.