The integration of actively-functional receptors into nanoscale networks outperformed competent detection devices and other ion-sensing designs. Synthesis of azo chromophores with long hydrophobic tails showed an ecofriendly sensing and an extreme selectivity for divalent mercury analytes. In order to tailor the tip to Hg-II ion-sensing functionality, we manipulated the chromophores into nanoscale membrane discs, which led to small, easy-to-use optical sensor strips. The design of these hydrophobic probes into ordered pore-based membranes transformed the ion-sensing systems into smart, stable assemblies and portable laboratory assays. The nanosensor membrane strips with chemical and mechanical stability allowed for reversible, stable and reusable detectors without any structural damage, even under rigorous chemical treatment for several numbers of repeated cycles. The optical membrane strips provided Hg-II ion-sensing recognition for both cost-and energy-saving systems. Indeed, the synthetic strips proved to have an efficient ability for various analytical applications, targeting especially for on-site and in situ chemical analyses, and for continuous monitoring of toxic Hg-II ions. On the proximity-sensing front, these miniaturized nanomembrane strips can revolutionize the consumer and industrial market with the introduction of the probe surface-mount naked-eye ion-sensor strips.