Characterization of PVA/glycerin hydrogels using γ-irradiation for advanced wound dressings

Young-Chang Nho; Youn-Mook Lim; Sung-Jun An; Min-Ho Youn; Seol-Hee Han; Ho-Nam Chang; Hui-Jeong Gwon

Korean Journal of Chemical Engineering, Vol.26, No.6, 1686-1688, November, 2009

DOI10.1007/s11814-009-0246-z Export Citation

Characterization of PVA/glycerin hydrogels using γ-irradiation for advanced wound dressings

Young-Chang Nho^{1, †}, Youn-Mook Lim¹, Sung-Jun An¹, Min-Ho Youn¹, Seol-Hee Han¹, Ho-Nam Chang², and Hui-Jeong Gwon^{1, 2}

¹Radiation Research Center for Industry & Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 1266 Sinjeong-dong, Jeongeup-si, Jeonbuk 580-185, Korea
²Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science Technology, Daejeon 305-701, Korea

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The aim of this study was to investigate the enhanced absorption property of PVA/Glycerin (PVA/Gly) hydrogel for advanced wound dressing. A simple crosslinking method was introduced to prepare the PVA/Gly hydrogels with the use of γ-irradiation. An absorption ratio and thermal properties of the PVA/Gly hydrogels can be controlled by varying the irradiation dose and weight ratio of the PVA/Gly. When the PVA/Gly content was 20/5 wt% and the irradiation dose at 25 kGy, the PVA/Gly hydrogels showed excellent absorption properties (>350%). These results imply that the PVA/Gly hydrogel is highly absorbent and converts wound exudates to the hydrogel matrices that create a moist and clean environment in the wound healing process. Therefore, the PVA/Gly hydrogel prepared by this method can be used as an advanced wound dressing.

Keywords:Absorption;Gamma Irradiation;PVA/Glycerin Hydrogel;Wound Healing

[References]

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Rosiak JM, Ulanski P, Radiat. Phys. Chem., 55, 139 (1999)

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[1] Peppas NA, Merrill EW, J. Appl. Polym. Sci., 20, 1457 (1976)

[2] Risbud MV, Hardikar AA, Bhat SV, Bhonde RR, J. Control. Release, 68, 23 (2000)

[3] Winter GD, Nature, 193, 293 (1962)

[4] Qiu Y, Park K, Adv. Drug Deliv. Rev., 53, 321 (2001)

[5] Rosiak JM, J. Control. Release, 31, 9 (1994)

[6] Ajji Z, Othman I, Rosiak JM, Nucl. Instrum. Methods Phys. Res. Sect. B-Beam Interact. Mater. Atoms., 229, 375 (2005)

[7] Hirai T, Okinaka T, Amemiya Y, Kobayashi K, Hirai M, Hayashi S, Angew. Makromole. Chem., 240, 213 (1995)

[8] Hassan CM, Stewart JE, Peppas NA, Eur. J. Pharm. Biopharm., 49, 161 (2000)

[9] Li YL, Neoh KG, Kang ET, Polymer, 45(26), 8779 (2004)

[10] Seabra AB, De Oliveira MG, Biomaterials, 25, 3773 (2004)

[11] Barbani N, Bertoni F, Ciardeelli G, Cristallini C, Silvestri D, Coluccio ML, Giusti P, Eur. Polym. J., 41, 3004 (2005)

[12] Matsuyama H, Teramoto M, Urano H, J. Membr. Sci., 126(1), 151 (1997)

[13] Muhlebach A, Muller B, Pharisa C, Hofmann M, Seiferling B, Guerry D, J. Polym. Sci. A: Polym. Chem., 35(16), 3603 (1997)

[14] Sudhamania SR, Prasada MS, Sankarb KU, Food Hydrocolloid., 17, 245 (2003)

[15] Burczak K, Fujisato T, Hatada M, Ikada Y, Biomaterials, 15, 231 (1994)

[16] Muzzarelli RAA, Chitin. Pergamon press, Oxford, UK (1977)

[17] Roberts GAF, Taylor KE, Chem., 190, 951 (1989)

[18] Rosiak JM, Ulanski P, Radiat. Phys. Chem., 55, 139 (1999)