Preparation and characterization of PVA/PVP/glycerin/antibacterial agent hydrogels made by γ-irradiation followed by freeze-thawing

Young-Chang Nho; Youn-Mook Lim; Hui-Jeong Gwon; Eun-Kyung Choi

Korean Journal of Chemical Engineering, Vol.26, No.6, 1675-1678, November, 2009

DOI10.1007/s11814-009-0231-6 Export Citation

Preparation and characterization of PVA/PVP/glycerin/antibacterial agent hydrogels made by γ-irradiation followed by freeze-thawing

Young-Chang Nho^{1, †}, Youn-Mook Lim¹, Hui-Jeong Gwon^{1, 2}, and Eun-Kyung Choi³

¹Radiation Research Center for Industry & Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 1266 Sinjeong-dong, Jeongeup-si, Jeonbuk 580-185, Korea
²Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science Technology, Daejeon 305-701, Korea
³Department of Industrial Chemistry, Chungnam National University, Daejeon 305-764, Korea

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Hydrogels for wound dressings from a mixture of poly(vinyl alcohol) (PVA), poly(N-vinylpyrrolidone) (PVP), glycerin and an antibacterial agent were obtained by a γ-irradiation combined with freeze-thawing. The physical properties such as the gelation and swelling degree of the hydrogels were examined. When the PVP/PVA ratio was 6 : 4 (wt%) and prepared by combined irradiation and freeze-thawing, it showed an excellent swelling capacity (>1,200%). The antibacterial effect of the hydrogels containing the antibacterial agents was observed to be effective as the concentration of antibacterial agents increased. The results demonstrated that hydrogel in a proper blending ratio could be used as a wound dressing that can accelerate wound healing with an antibacterial effect.

Keywords:Hydrogels;Radiation;Antibacterial;Freeze-thawing

[References]

Muhlebach A, Muller B, Pharisa C, Hofmann M, Seiferling B, Guerry D, J. Polym. Sci. Pol. Chem., 35, 3603 (1996)
Peppas NA, Merrill EW, J. Appl. Polym. Sci., 20, 1457 (1976)
Rosiak JM, J. Control. Release, 31, 9 (1994)
Rosiak JM, Ulanski P, Pajewski LA, Yoshii F, Makuuchi K, Radiat. Phys. Chem., 46, 161 (1995)
Burczak K, Fujisato T, Hatada M, Ikada Y, Biomaterials, 15, 231 (1994)
Hirai T, Okinaka T, Amemiya Y, Kobayashi K, Hirai M, Hayashi S, Die Angewandte Makromolekulare Chemie, 240, 213 (1995)
Liu MZ, Cheng RS, Qian RY, J. Polym. Sci. B: Polym. Phys., 33(12), 1731 (1995)
Yeom CK, Lee KH, J. Membr. Sci., 109(2), 257 (1996)
Matsuyama H, Teramoto M, Urano H, J. Membr. Sci., 126(1), 151 (1997)
Zhai M, Ha H, Yoshii F, Makuuchi K, Radiat. Phys. Chem., 57, 459 (2000)
Rosiak JM, Ulanski P, Radiat. Phys. Chem., 55, 139 (1999)
Kim TH, Nho YC, Polym.(Korea), 25(2), 270 (2001)
Park KR, Nho YC, Polym.(Korea), 26(6), 792 (2002)
Ma NL, Chem. Phys. Lett., 297, 230 (1998)
Tranquilan-Aranilla C, Yoshii F, Dela AM, Makuuch K, Radiat. Phys. Chem., 55, 127 (1999)
Miranda LF, Lugao AB, Machado LDB, Ramanthan LV, Radiat. Phys. Chem., 55, 709 (1999)
Damian G, Talanta, 60, 923 (2003)
Zegota H, Koprowski M, Zegota A, Radiat. Phys. Chem., 45, 223 (1995)

[Referenced By]

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[1] Muhlebach A, Muller B, Pharisa C, Hofmann M, Seiferling B, Guerry D, J. Polym. Sci. Pol. Chem., 35, 3603 (1996)

[2] Peppas NA, Merrill EW, J. Appl. Polym. Sci., 20, 1457 (1976)

[3] Rosiak JM, J. Control. Release, 31, 9 (1994)

[4] Rosiak JM, Ulanski P, Pajewski LA, Yoshii F, Makuuchi K, Radiat. Phys. Chem., 46, 161 (1995)

[5] Burczak K, Fujisato T, Hatada M, Ikada Y, Biomaterials, 15, 231 (1994)

[6] Hirai T, Okinaka T, Amemiya Y, Kobayashi K, Hirai M, Hayashi S, Die Angewandte Makromolekulare Chemie, 240, 213 (1995)

[7] Liu MZ, Cheng RS, Qian RY, J. Polym. Sci. B: Polym. Phys., 33(12), 1731 (1995)

[8] Yeom CK, Lee KH, J. Membr. Sci., 109(2), 257 (1996)

[9] Matsuyama H, Teramoto M, Urano H, J. Membr. Sci., 126(1), 151 (1997)

[10] Zhai M, Ha H, Yoshii F, Makuuchi K, Radiat. Phys. Chem., 57, 459 (2000)

[11] Rosiak JM, Ulanski P, Radiat. Phys. Chem., 55, 139 (1999)

[12] Kim TH, Nho YC, Polym.(Korea), 25(2), 270 (2001)

[13] Park KR, Nho YC, Polym.(Korea), 26(6), 792 (2002)

[14] Ma NL, Chem. Phys. Lett., 297, 230 (1998)

[15] Tranquilan-Aranilla C, Yoshii F, Dela AM, Makuuch K, Radiat. Phys. Chem., 55, 127 (1999)

[16] Miranda LF, Lugao AB, Machado LDB, Ramanthan LV, Radiat. Phys. Chem., 55, 709 (1999)

[17] Damian G, Talanta, 60, 923 (2003)

[18] Zegota H, Koprowski M, Zegota A, Radiat. Phys. Chem., 45, 223 (1995)