The sol-gel derived polymer/silicate hybrid materials have attracted considerable attention in recent years. The incorporation of silicate phase into polymeric materials may constitute an important tool to either enhance mechanical properties or provide more biocompatibility to the resulting hybrids. PHEA, α-β-poly(N-2-hydroxyethyl-DL-aspartamide), is a class of poly(amino acid)s that has been widely studied as a biodegradable functional polymer with potential biomedical and pharmaceutical applications. Hydrogels from PHEA are formed easily by a chemical or physical crosslinking reaction but the resulting gels are mechanically weak and less thermally stable. In this study, hybrid materials were prepared based on PHEA and silicate. A sol-gel process was employed using TEOS and modified PHEA to introduce inorganic silicate phase within the polymer gel matrix. FT-IR and NMR were used to analyze the chemical structure of the PHEA derivatives. In addition, the morphology, thermal and swelling properties of the hybrid gels were examined.