This work presents a generic modeling framework for the separation of gas mixtures using multibed pressure swing adsorption (PSA) processes. Salient features of the model include various mass, heat, and momentum transport mechanisms, gas valve models, complex boundary conditions, and realistic operating procedures. All models have been implemented in the gPROMS modeling environment and a formal and user-friendly automatic procedure for generating multibed configurations of arbitrary complexity has been developed. The predictive power of the developed modeling framework for various PSA multibed configurations has been validated against literature and experimental data. The effect of various operating conditions on the product purity and recovery is systematically analyzed. Typical trade offs between capital and operating costs are revealed.