Based on the Response Surface Methodology (RSM), the development of first- and second-order models for predicting the Air Diffusion Performance Index (ADPI) in a displacement-ventilated office is presented. By adopting the technique of Computational Fluid Dynamics (CFD), the new ADPI models developed are used to investigate the effect of simultaneous variation of three design variables in a displacement ventilation case, i.e. location of the displacement diffuser (L-dd), supply temperature (T) and exhaust position (L-cx) on the comfort parameter ADPI. The RSM analyses are carried out with the aid of a statistical software package MINITAB. In the current study, the separate effect of individual design variable as well as the second-order interactions between these variables, are investigated. Based on the variance analyses of both the first- and second-order RSM models, the most influential design variable is the supply temperature. In addition, it is found that the interactions of supply temperature with other design variables are insignificant, as deduced from the second-order RSM model. The optimised ADPI value is subsequently obtained from the model equations. (C) 2007 Elsevier B.V. All rights reserved.