In the last years, boron and arsenic are gaining wide attention in the water treatment community due to their adverse effects both on human/animal health and on agriculture. As a consequence, nowadays, the number of water treatment plants equipped with boron and arsenic removal facilities is growing. Usually it is difficult to remove them from water due to their size and charge. Therefore, in order to obtain substantial arsenic and boron reduction in the treated water, the most part of the desalination/purification plants have to use chemicals agents and Reverse Osmosis (RO) systems with several pass-stages. In this paper the potentialities of Membrane Distillation (MD) as a new and innovative technique for contaminants removal from water were investigated. The purposes of the present work are as follows: 1) to examine the efficiency of different pressure driven membrane processes for boron and arsenic removal from water; 2) to test experimentally the performance of Membrane Distillation for water purification; 3) to analyse and propose an innovative integrated system for the contaminants removal from water. In the proposed flow sheet, pressure-driven membrane operations have been synergically joined with membrane distillation technology for reaching the Process lntensification goals thanks to the possibility of overcoming the limits of the single units and, thus, to improve the performance of the overall operation. The designed system is constituted by a Reverse Osmosis (RO) step followed by a Membrane Distillation (MD) one. In this process in order to achieve, in the produced fresh water, a boron and arsenic concentration equal or less the maximum recommended values, only 36% of the RO permeate has to be sent to the MD module. Moreover MD operation allows total boron arsenic removal from water without the use of chemical agents, which results in less chemical cost and, above all, in a less environmental impact.