Polyamide 66(PA66)/clay nanocomposites were prepared by direct melt compounding. The mechanical and tribological properties were evaluated. It was found that addition of clay into PA66 increased the bending strength and microhardness of PA66. And also, the incorporation of clay can reduce the friction coefficient of PA66. The nanocomposites which have the mass fraction less than 5% show less wear rate compared with neat PA66. High fraction of clay can cause severe agglomerated abrasives. The differences in the friction and wear behaviors of PA66 and PA66/clay nanocomposites are attributed to the differences in their surface morphologies, transfer film characteristic. The agglomerated abrasives on the worn surface contribute to the increase of wear rate of nanocomposites of higher mass fraction clay. The friction and wear behaviors of PA66 and its nanocomposites under high temperature exhibit similar tendency with those under 25 degrees C.