(R)-(+) and (S)-(-) ethyl 4,4,4-trifluoro-3-hydroxy butanoate by enantioselective Baker's yeast reduction

Davoli P; Forni A; Moretti I; Prati F; Torre G

Enzyme and Microbial Technology, Vol.25, No.1-2, 149-152, 1999

DOI10.1016/S0141-0229(99)00025-3 Export Citation

(R)-(+) and (S)-(-) ethyl 4,4,4-trifluoro-3-hydroxy butanoate by enantioselective Baker's yeast reduction

Davoli P, Forni A, Moretti I, Prati F, Torre G

(R)-(+) and (S)-(-) ethyl 4,4,4-trifluoro-3-hydroxybutanoate are obtained both by enantioselective Baker's yeast reduction of ethyl 4,4,4-trifluoro-3-oxobutanoate in the presence of allyl bromide or allyl alcohol. The two additives act as inhibitors of Si or Re yeast-enzymes, respectively.

Keywords:BETA-KETO-ESTERS;STEREOCHEMICAL CONTROL;MICROBIAL REDUCTION;ABSOLUTE-CONFIGURATION;DERIVATIVES

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