Ketone super silyl enol others are shown to be excellent nucleophiles in the Mukaiyama aldol reaction as well as in sequential one-pot diasterreoselective reactions. High yields and diastereoselectivities are obtained with a variety of sityl enol other/aldegyde/Grignard combinations. The utility of this reaction is exemplified in a one-pot 4-component reaction generating tow secondary and one tertiary alcohol in one step.