화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.33, No.3, 248-253, May, 2009
Export Citation
PCL/PCL-g-PEG 생분해성 블렌드에서 그래프트 공중합체의 조성에 따른 상용성의 영향
Effect of Graft Copolymer Composition on the Compatibility of Biodegradable PCL/PCL-g-PEG Blend
조국영†, 이기석1, 박정기2
  • 공주대학교 신소재공학부
  • 1공주대학교 기계자동차공학부
  • 2KAIST 생명화학공학과
Kuk Young Cho†, Ki Seok Lee1, and Jung-Ki Park2
  • Division of Advanced Materials Engineering, Kongju National University, 275 Budae-dong, Cheonan, Chungnam 303-717, Korea
  • 1Department of Mechanical Engineering & Automotive Engineering, Kongju National University, 275 Budae-dong, Cheonan, Chungnam 303-717, Korea
  • 2Department of Chemical & Biomolecular Engineering, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701, Korea
E-mail:
초록
의료용으로 적용될 수 있는 새로운 재료를 제조하기 위하여 폴리카프로락톤(PCL)과 양친성 구조를 갖는 폴리(에틸렌 글리콜)(PEG)이 그래프트된 PCL을 이용하여 생분해성 블렌드를 제조하였다. 제조된 블렌드는 PCL을 기본으로 하고 여기에 그래프트 공중합체의 함량을 변화시키며 열적 그리고 결정화 특성을 관찰하였다. 그래프트 공중합체의 함량 변화에 따라 결정화 온도의 변화 및 결정화 속도가 변화하였고 이를 통해 그래프트 공중합체가 PCL의 결정화 거동에 영향을 미침을 확인하였다. 이는 광학현미경을 통한 결정의 교대 소광 밴드의 관찰을 통하여서도 확인할 수 있었다. 약물방출시스템과 같은 의료용 응용을 고려하여 블렌드 필름의 흡수거동과 단백질 흡착에 대한 특성도 평가하였다.
Blend films based on the poly(ε-caprolactone) (PCL) and amphiphilic biodegradable polymer, poly(ethylene glycol) grafted poly(ε-caprolactone) (PCL-g-PEG), were prepared with different blend ratios in order to develop new biomedical material. PCL was the main component in the blend. The miscibility and characteristics of the blends were investigated. The crystallization temperature of the blend shifted to high temperatures with an increase of the graft copolymer contents when the homopolymer PCL was the main component of the blend. The PEG side chain in the blend affected the crystallization rate of the PCL crystals in the blend and alternating extinction bands were observed by optical microscopy. The protein adhesion behavior of the film was influenced by the water uptake of the film.
Keywords:blend;poly(ε-caprolactone);poly(ethylene glycol);crystallization;protein adhesion.
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