PBAST/PVA 이중층 중공미세구의 제조에 관한 연구

송명숙; 우제완; Myung Sook Song; Je-Wan Woo

Clean Technology, Vol.14, No.4, 256-264, December, 2008

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PBAST/PVA 이중층 중공미세구의 제조에 관한 연구

A Study on the Preparation of PBAST/PVA Double Layered Hollow Microspheres

송명숙, 우제완 ^†

상명대학교 공업화학과, 110-743 서울특별시 종로구 홍지동 7번지

Myung Sook Song, and Je-Wan Woo^†

Department of Industrial Chemistry, Sangmyung lJniversity, 7 Hongji-dong, Jongro-gu, Seoul 110-743, Korea

E-mail:

초록

본 연구에서는 생분해가 가능하여 친환경성이 우수한 지방족 폴리에스터 중에서 PBAST를 이용하여, 다중유화법(W1/O/W2)에 의해 PBAST/PVA 두층을 갖는 중공미세구를 제조하였다. 최적의 이중층 중공미세구를 얻을 수 있는 조건은, 유기상에서 의 PBAST고분자의 농도 5 wt%, 내부 수용액 상에서의 PVA의 농도 5 wt%, W1/O emulsion과 외부 수용액상의 비율이 1:4.5이었고 계면활성제는 단일 성분을 사용하는 경우보다 HLB 값의 차이가 큰 보조계면활성제(co-surfactant)를 사용하는 경우였으며, 이때 PBAST/PVA 이중층중공미세구(double-layered microsphere)의 제조 수율은 30.92%, 미세구의 총괄밀도(bulk density)는 0.180 g/ml이며 입자크기는 1.5~3 μm로 고른 분포를 나타내었다.

In this study, using PBAST (poly(butylene adipate-co-succinate-co-terephthalate)) which was eco-friendly biodegradable aliphatic polyester, PBAST/PVA (poly(vinyl alcohol)) double-layered hollow microspheres were prepared with the water/oil/water multiple emulsion (W1/O/W2) method. The double-layered hollow microspheres were manufactured with the yield of 30.92% when the concentration of polymer PBAST in organic phase was 5 wt%, the concentration of PVA in inner aqueous phase was 5 wt%, the volume ratio of W1/O emulsion to outer aqueous phase was 1:4.5, and when co-surfactants that had large gap in HLB (hydrophile-lipophile balance) value were used. The bulk density of prepared hollow microsphere was 0.180 g/ml and particle size was 1.5~3 μm.

Keywords:지방족 폴리에스터;생분해성 고분자;중공미세구;다증유화법;Aliphatic polyester;Biodegradable polymer;PBAST;Hollow microspheres;Multiple emulsion (W1/O/W2) method

[References]

Wilcox DL, MRS Symp. Proc., 372 (2005)
Bertling J, Blomer J, Kummel R, Chem. Eng. Technol., 27(8), 829 (2004)
Johnson KA, Adv. Drug Deliver. Rev., 26, 3 (1997)
Takagi M, J. Vnc. Sci. Technol., A9, 2145 (1991)
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O'Donnell B, McGinity JW, Adv. Drug Deliver. Rev., 28, 25 (1997)
Takada S, Yamagata Y, Misaki M, Taira K, Kurokawa T, J. Control Release, 88, 229 (2003)
Sun G, Zhang Z, Int. J. Pharm., 242, 307 (2002)
Tunuli MS, Fendler JH, J. Am. Chem. Soc., 103, 2507 (1981)
Zhou XH, Li WPA, Int. J. Pharm., 75, 97 (1991)
Ogawa Y, Yamamto M, Okada H, Yashiki T, Shimamoto T, Chem Pharm. Bull, 36, 1095 (1998)
Kidchob T, Kimura S, Imanishi Y, J. Control Release, 54, 283 (1998)
Park SJ, Shin YS, Lee JR, J. Colloid Interface Sci., 241(2), 502 (2001)
Hirech K, Payan S, Carnelle G, Brujes L, Legrand J, Powder Technol., 130(1-3), 324 (2003)
Stockes RA, Coppedge JR, Ridgway RL, J. Agr. Food Chem., 18, 195 (1970)
Smith KL, .Schimpf ME, Thompson KE, Adv. Drug Deliver. Rev., 4, 343 (1990)
Gen LM, Zhang K, Chew CH, Colloid. Surfaces A, 110, 199 (1996)
Crotts G, Park TG, J. Control. Release, 35, 91 (1995)
Arshady R, George MH, Polym. Eng. Sci., 33, 865 (1993)
Park YS, Youn ES, J. Korean Ind. Eng. Chem., 15(1), 59 (2004)
Kwon SY, Woo JW, Clean Technol., 12(4), 205 (2006)

[Related Articles]

[1] Wilcox DL, MRS Symp. Proc., 372 (2005)

[2] Bertling J, Blomer J, Kummel R, Chem. Eng. Technol., 27(8), 829 (2004)

[3] Johnson KA, Adv. Drug Deliver. Rev., 26, 3 (1997)

[4] Takagi M, J. Vnc. Sci. Technol., A9, 2145 (1991)

[5] Morita T, Horikiri Y, Suzuki T, Yoshino H, Int. J. Pharrm., 219, 127 (2001)

[6] O'Donnell B, McGinity JW, Adv. Drug Deliver. Rev., 28, 25 (1997)

[7] Takada S, Yamagata Y, Misaki M, Taira K, Kurokawa T, J. Control Release, 88, 229 (2003)

[8] Sun G, Zhang Z, Int. J. Pharm., 242, 307 (2002)

[9] Tunuli MS, Fendler JH, J. Am. Chem. Soc., 103, 2507 (1981)

[10] Zhou XH, Li WPA, Int. J. Pharm., 75, 97 (1991)

[11] Ogawa Y, Yamamto M, Okada H, Yashiki T, Shimamoto T, Chem Pharm. Bull, 36, 1095 (1998)

[12] Kidchob T, Kimura S, Imanishi Y, J. Control Release, 54, 283 (1998)

[13] Park SJ, Shin YS, Lee JR, J. Colloid Interface Sci., 241(2), 502 (2001)

[14] Hirech K, Payan S, Carnelle G, Brujes L, Legrand J, Powder Technol., 130(1-3), 324 (2003)

[15] Stockes RA, Coppedge JR, Ridgway RL, J. Agr. Food Chem., 18, 195 (1970)

[16] Smith KL, .Schimpf ME, Thompson KE, Adv. Drug Deliver. Rev., 4, 343 (1990)

[17] Gen LM, Zhang K, Chew CH, Colloid. Surfaces A, 110, 199 (1996)

[18] Crotts G, Park TG, J. Control. Release, 35, 91 (1995)

[19] Arshady R, George MH, Polym. Eng. Sci., 33, 865 (1993)

[20] Park YS, Youn ES, J. Korean Ind. Eng. Chem., 15(1), 59 (2004)

[21] Kwon SY, Woo JW, Clean Technol., 12(4), 205 (2006)