Alginate Nanohydrogels Prepared by Emulsification-Diffusion Method

So Min Lee; Eun Soo Yoo; Han Do Ghim; Su Jeong Lee

Macromolecular Research, Vol.17, No.3, 168-173, March, 2009

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Alginate Nanohydrogels Prepared by Emulsification-Diffusion Method

So Min Lee, Eun Soo Yoo, Han Do Ghim^†, and Su Jeong Lee¹

Department of Advanced Organic Materials Science and Engineering, Kyungpook NationalUniversity, Daegu 702-701, Korea
¹Display Materials Team, Electro-Materials BG, R&D Center, Doosan Co., Gyeonggido 448-795, Korea

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This study reports the preparation and characterization of nanohydrogels by using sodium alginate as a model material. Alginate nanohydrogels (ANH) were prepared by emulsification-diffusion method in a w/o system with 1,2-diacyl-sn-glycero-3-phosphocholin as the lipophilic surfactant. The effects of the alginate to surfactant ratio and the remaining water contents on the mean particle size and swellability of ANHs were investigated in terms of the concentration, agitation speed, and agitation time. The feasibility of using nanohydrogels and their controllability were proved by the water the absorbency of ANHs during a 7-day evaluation by dynamic light scattering. In this work, the mean particle sizes of ANHs could be controlled from 49.2 nm (measured in ethanol phase) to 1.9 μm (measured in water phase, after 7 days of water absorption).

Keywords:alginate;nanohydrogel;emulsification-diffusion method;swelling;water absorption.

[References]

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Tan WB, Zhang Y, J. Nanosci. Nanotechno., 7, 2389 (2007)
Morello AP, Burrill R, Mathiowitz E, J. Microencapsul., 24, 476 (2007)
Guo J, Yang W, Deng Y, Wang C, Fu S, Small, 1, 737 (2005)
Sarmento B, Ribeiro AJ, Veiga F, Ferreira DC, Neufeld RJ, J. Nanosci. Nanotechno., 7, 2833 (2007)
Gan Q, Wang T, Colloid Surface B, 59, 24 (2007)
Kreuter J, in Encyclopedia of Nanoscience and Nanotechnology, Nalwa HS, Ed., American Scientific Publishers, California, 2004, Vol. 7, pp 162-166
Quintanar-Guerrero D, Allemann E, Doelker E, Fessi H, Pharm. Res., 15, 1056 (1998)
Kwon HY, Lee JY, Choi SW, Jang Y, Kim JH, Colloid Surface A, 182, 123 (2001)
Lee S, Jeong J, Shin S, Kim J, Chang Y, Chang Y, Kim J, J. Magn. Magn. Mater., 272, 2432 (2004)
Lee S, Jeong J, Shin S, Huh Y, Song H, Suh J, Chang Y, Jeon B, Kim J, J. Appl. Phys., 97, 10Q913 (2005)
Lee S, Jeong J, Shin S, Kim J, Chang Y, Lee W, Kim J, Colloid Surface A, 255, 19 (2005)
Im SJ, Choi YM, Subramanyam E, Huh KM, Park K, Macromol. Res., 15(4), 363 (2007)
Liu Y, Wang S, Krouse J, Kotov NA, Eghtedari M, Vargas G, Motamedi M, J. Biomed. Mater. Res. A, 83A, 1 (2007)
Seo J, Jang W, Han H, Macromol. Res., 15(1), 10 (2007)
Lee CM, Jeong HJ, Kim DW, Lee KY, Macromol. Res., 16(5), 429 (2008)
Byun H, Hong B, Nam SY, Jung SY, Rhim JW, Lee SB, Moon GY, Macromol. Res., 16(3), 189 (2008)
Rubinstein A, Drug. Develop. Res., 50, 435 (2000)
Han IS, Han MH, Kim J, Lew S, Lee YJ, Horkay F, Magda JJ, Biomacromolecules, 3(6), 1271 (2002)
Wu XJ, Choi MMF, Anal. Chem., 76, 4279 (2004)
Martin DK, J. Biomed. Mater. Res., 29, 857 (1995)
Gonzalez-Meijome JM, Lopez-Alemany A, Almeida JB, Parafita MA, Refojo MF, J. Biomed. Mater. Res. B, 83B, 512 (2007)
Ueng SWN, Lee MS, Lin S, Chan E, Liu S, J. Orthop. Res., 25, 62 (2007)
Serp D, Cantana E, Heinzen C, von Stockar U, Marison IW, Biotechnol. Bioeng., 70(1), 41 (2000)
Li RH, Altreuter DH, Gentile FT, Biotechnol. Bioeng., 50(4), 365 (1996)
Suzuki Y, Tanihara M, Nishimura Y, Suzuki K, Yamawaki Y, Kudo H, Kakimaru Y, Shimizu Y, J. Biomed. Mater. Res., 48, 522 (1999)
Suzuki Y, Nishimura Y, Tanihara M, Suzuki K, Nakamura T, Shimizu Y, Yamawaki Y, Kakimaru Y, J. Biomed. Mater. Res., 39, 317 (1998)
Wang L, Khor E, Wee A, Lim LY, J. Biomed. Mater Res., 63, 610 (2002)
Milella E, Barra G, Ramires PA, Leo G, Aversa P, Romito A, J. Biomed. Mater. Res., 57, 248 (2001)
Ishikawa K, Ueyama Y, Mano T, Koyama T, Suzuki K, Matsumura T, J. Biomed. Mater. Res., 47, 111 (1999)
Lei J, Kim JH, Jeon YS, Macromol. Res., 16(1), 45 (2008)
Downs EC, Robertson NE, Riss TL, Plunkett ML, J. Cell. Physiol., 152, 422 (1992)
O’Neil MJ, Ed., in Merck Index, Merck & Co., Inc., NJ (2006)
Carrella M, Feldman D, Cogoi S, Csillaghy A, Weinhold PA, Hepatology, 29, 1825 (1999)
Fujii DK, Cheng J, Gospodarowicz D, J. Cell. Physiol., 114, 267 (1983)

[Referenced By]

[1] Pressly ED, Rossin R, Hagooly A, Fukukawa KI, Messmore BW, Welch MJ, Wooley KL, Lamm MS, Hule RA, Pochan DJ, Hawker CJ, Biomacromolecules, 8(10), 3126 (2007)

[2] Tan WB, Zhang Y, J. Nanosci. Nanotechno., 7, 2389 (2007)

[3] Morello AP, Burrill R, Mathiowitz E, J. Microencapsul., 24, 476 (2007)

[4] Guo J, Yang W, Deng Y, Wang C, Fu S, Small, 1, 737 (2005)

[5] Sarmento B, Ribeiro AJ, Veiga F, Ferreira DC, Neufeld RJ, J. Nanosci. Nanotechno., 7, 2833 (2007)

[6] Gan Q, Wang T, Colloid Surface B, 59, 24 (2007)

[7] Kreuter J, in Encyclopedia of Nanoscience and Nanotechnology, Nalwa HS, Ed., American Scientific Publishers, California, 2004, Vol. 7, pp 162-166

[8] Quintanar-Guerrero D, Allemann E, Doelker E, Fessi H, Pharm. Res., 15, 1056 (1998)

[9] Kwon HY, Lee JY, Choi SW, Jang Y, Kim JH, Colloid Surface A, 182, 123 (2001)

[10] Lee S, Jeong J, Shin S, Kim J, Chang Y, Chang Y, Kim J, J. Magn. Magn. Mater., 272, 2432 (2004)

[11] Lee S, Jeong J, Shin S, Huh Y, Song H, Suh J, Chang Y, Jeon B, Kim J, J. Appl. Phys., 97, 10Q913 (2005)

[12] Lee S, Jeong J, Shin S, Kim J, Chang Y, Lee W, Kim J, Colloid Surface A, 255, 19 (2005)

[13] Im SJ, Choi YM, Subramanyam E, Huh KM, Park K, Macromol. Res., 15(4), 363 (2007)

[14] Liu Y, Wang S, Krouse J, Kotov NA, Eghtedari M, Vargas G, Motamedi M, J. Biomed. Mater. Res. A, 83A, 1 (2007)

[15] Seo J, Jang W, Han H, Macromol. Res., 15(1), 10 (2007)

[16] Lee CM, Jeong HJ, Kim DW, Lee KY, Macromol. Res., 16(5), 429 (2008)

[17] Byun H, Hong B, Nam SY, Jung SY, Rhim JW, Lee SB, Moon GY, Macromol. Res., 16(3), 189 (2008)

[18] Rubinstein A, Drug. Develop. Res., 50, 435 (2000)

[19] Han IS, Han MH, Kim J, Lew S, Lee YJ, Horkay F, Magda JJ, Biomacromolecules, 3(6), 1271 (2002)

[20] Wu XJ, Choi MMF, Anal. Chem., 76, 4279 (2004)

[21] Martin DK, J. Biomed. Mater. Res., 29, 857 (1995)

[22] Gonzalez-Meijome JM, Lopez-Alemany A, Almeida JB, Parafita MA, Refojo MF, J. Biomed. Mater. Res. B, 83B, 512 (2007)

[23] Ueng SWN, Lee MS, Lin S, Chan E, Liu S, J. Orthop. Res., 25, 62 (2007)

[24] Serp D, Cantana E, Heinzen C, von Stockar U, Marison IW, Biotechnol. Bioeng., 70(1), 41 (2000)

[25] Li RH, Altreuter DH, Gentile FT, Biotechnol. Bioeng., 50(4), 365 (1996)

[26] Suzuki Y, Tanihara M, Nishimura Y, Suzuki K, Yamawaki Y, Kudo H, Kakimaru Y, Shimizu Y, J. Biomed. Mater. Res., 48, 522 (1999)

[27] Suzuki Y, Nishimura Y, Tanihara M, Suzuki K, Nakamura T, Shimizu Y, Yamawaki Y, Kakimaru Y, J. Biomed. Mater. Res., 39, 317 (1998)

[28] Wang L, Khor E, Wee A, Lim LY, J. Biomed. Mater Res., 63, 610 (2002)

[29] Milella E, Barra G, Ramires PA, Leo G, Aversa P, Romito A, J. Biomed. Mater. Res., 57, 248 (2001)

[30] Ishikawa K, Ueyama Y, Mano T, Koyama T, Suzuki K, Matsumura T, J. Biomed. Mater. Res., 47, 111 (1999)

[31] Lei J, Kim JH, Jeon YS, Macromol. Res., 16(1), 45 (2008)

[32] Downs EC, Robertson NE, Riss TL, Plunkett ML, J. Cell. Physiol., 152, 422 (1992)

[33] O’Neil MJ, Ed., in Merck Index, Merck & Co., Inc., NJ (2006)

[34] Carrella M, Feldman D, Cogoi S, Csillaghy A, Weinhold PA, Hepatology, 29, 1825 (1999)

[35] Fujii DK, Cheng J, Gospodarowicz D, J. Cell. Physiol., 114, 267 (1983)