The object of this study is to test solubility of methoxy poly (ethylene glycol) (MPEG)-grafted chitosan copolymer in the organic solvents and aqueous solution. Water-soluble chitosan with low molecular weight (LMWSC) was used to synthesis of PEG-graft copolymerization. MPEG was conjugated to the water soluble chitosan using 4-dicyclohexylcarbodimide (DCC) and N-hydroxysuccimide (NHS). Introduction of PEG was confirmed by JH NMR spectroscopy. Degree of substitution (DS) of MPEG into chitosan was calculated from JH NMR results. From these results. Furthermore, introduction of PEG into chitosan increases the solubility in aqueous solution with various organic solvent such as DMF, DMSO, ethanol and acetone.