The solubilities of rutin in water, methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, acetone, and ethyl acetate were determined at T= 283.15, 298.15, 313.15, 323.15, and 333.15 K using RP-HPLC. The solubilities of rutin in pure solvents increase with increasing temperature except ethyl acetate. A simplified thermodynamic equation and an empirical equation were used to correlate the experimental data. These data of solubility can be used to purify the reaction mixture system. (c) 2007 Elsevier B.V. All rights reserved.