The introduction of natural gas in the Greek energy market broadened the options in the field of space heating. Residents in five major Greek cities can choose from a variety of different fuels and systems for heating their houses or working spaces; 12 more cities will be connected to the gas network within the next 5 years. Considering that space heating is the major energy consuming activity in the Greek building sector and that the environmental constrains imposed by the Kyoto protocol will be met only with difficulty, if at all, a strategy concerning the developments in space heating seems to be necessary. This however presupposes an elaborate analysis of the overall performance of the alternative systems, taking into consideration the particular conditions of the Greek energy system and the 'established' way of designing residential and mixed-use buildings. The present paper aims to present the empirical comparative results related to the three most popular heating systems operated in Greek multi-apartment and mixed-use buildings, which use three different fuels, respectively: a central oil-fired boiler, a unitary gas-fired boiler and unitary heat pumps. (c) 2007 Elsevier B.V.. All fights reserved.