화학공학소재연구정보센터
Journal of Molecular Catalysis A-Chemical, Vol.275, No.1-2, 148-152, 2007
Microwave-assisted and Zn[L-proline](2) catalyzed tandem cyclization under solvent free conditions: Rapid synthesis of chromeno[4,3-c]pyrazol-4-ones
Present study and investigations reveals that, the hydrazones of 3-acetyl-4-hydi-oxycourriarin undergo ring cyclization to give, 3-methyl-1-substituted phenyl-]H-chromeno[4,3-c]pyrazol-4-ones (2a-m) under the influence of microwave irradiation and by using Zn[L-proline](2), a novel Lewis acid catalyst. The overall yields of the products were found to be 82-93%. Without use of the catalyst, no reaction progress was observed. No significant changes in the overall yields of the products were observed at high microwave power and at high temperatures. The reusability of the catalyst was also checked and found up to seven cycles. (c) 2007 Elsevier B.V. All rights reserved.