Journal of Molecular Catalysis A-Chemical, Vol.274, No.1-2, 83-86, 2007
Rare-earth metal triflates catalyzed three-component coupling of aldehydes, ketones or ketoesters and benzyl carbamate: An efficient one-pot stereoselective synthesis of Cbz-protected beta-amino carbonyl compounds
Sc(OTf)(3) and Yb(OTf)(3) have been found to be efficient catalysts for one-pot three-component coupling of aldehydes, ketones or ketoesters and benzy carbamate in acetonitrile at room temperature to furnish the corresponding Cbz-protected beta-amino ketones in impressive yields and good diastereoselectivity. (c) 2007 Elsevier B.V. All rights reserved.
Keywords:Sc(OTf)(3);Yb(OTf)(3);Cbz-protected beta-amino ketone;three-component coupling;diastereoselectivity