We report the complexation of a series of n(-) and cycloalkanes by an anionic, metal-ligand cluster carrying a 12(-) charge. This host also encapsulates cyclodecane isomers such as adamantane, the dicyclopentadienes, and the decalins. The relative binding affinities of these guests for the [Ga4L6](12-) cluster are reported and attributed to the hydrophobic effect.