Journal of the American Chemical Society, Vol.129, No.37, 11340-11340, 2007
Intramolecular Heck reactions of unactivated alkyl halides
A method has been developed for achieving palladium-catalyzed intramolecular Heck reactions of unactivated, beta-hydrogen-containing alkyl bromides and chlorides. The data from a stereochemical investigation are consistent with carbon-carbon bond formation via an alkylpalladium, rather than a radical, intermediate.