The Solution-Enhanced Dispersion by Supercritical Fluids (SEDS) process is a promising technology for the production of ultrafine powders, composite microparticles, and other powders. Carotene/proanthocyanidin composite microparticles were obtained using supercritical CO2 (SC-CO2) as an antisolvent in a mixed solution of dichloromethane and ethanol. For the purpose of evaluating the efficiency of the supercritical fluid precipitation technologies in processing the composite microparticles and studying the effects of operating variables on the composite microparticle, the SEDS process through Prefilming Atomization (SEDS-PA) was used in this paper. Morphologies and particle sizes of the composite microparticles were analyzed by scanning electron microscopy and optical microscopy. The carotene concentrations in the composite microparticles were determined by spectrophotometry. The results show that the precipitates obtained under the experimental conditions are platelet-shaped carotene and proanthocyanidin composite microparticles with a mean particle size of 2-5 mu m. The particle sizes of the composite microparticles increase as the temperature increases and decrease as the pressure and carotene concentration in the mixed solution each increase. The carotene concentration in the composite microparticles increases initially, then decreases with increasing temperature, and increases with increasing carotene concentration in the mixed solution, and no clear change dependence on pressure can be observed. The proanthocyanidins can effectively restrain the degradation of carotene in the composite microparticles.