Fischer-Tropsch Synthetic Crude is high in olefinicity and needs further hydroprocessing to conform to fuel specifications such as oxidation stability. Different catalysts, that is, sulfided NiMo/Al2O3, CoMo/Al2O3, and unsulfided Ni/Al2O3, have been used, and a kinetic model has been derived for the hydrogenation of Fischer-Tropsch Synthetic Crude. The kinetic model allows for predicting process conditions necessary to meet mandatory fuel specifications and market requirements as well as to compare the catalytic activity of these different hydrogenation catalysts on the basis of the kinetic parameters.