A concept of the safety boundary diagram, elaborated in our previous studies for liquid-liquid heterogeneous reactions, has been developed here for liquid-phase homogeneous semibatch reactors. With the use of this boundary diagram, inherently safe-operating conditions can be easily determined without costly and time-consuming kinetic studies. A rapid procedure to estimate the dosing time and the cooling temperature appropriate for inherently safe operation of the reactor has been elaborated and proposed. (c) 2007 Elsevier Ltd. All rights reserved.